RABBIT ANTI CHICKEN INTERFERON ALPHA:Preservative Free MBS220074 from MyBioSource.com

Description

MBS220074 recognizes chicken Interferon alpha (chIFNalpha). The classification of mammalian cytokines with antiviral activity, is well documented as being either Type I Interferon (IFNI) or Type II Interferon (IFNII). This is not the case for avian IFNs however, even though IFN was first detected in the chicken. A growing number of functional studies indicate similarities between chicken IFN and mammalian IFNI, revealing the conservation of cysteine residues and the existence of around ten closely related intron-less IFN alpha genes. Further research has shown that chIFN-alpha genes are strongly expressed following viral infection of monocyte-derived macrophage and embryo fibroblasts and that recombinant chicken IFN acts as a potent antiviral agent. MBS220074 cross reacts with IFN beta in western blots but does not show any cross reactivity with IFN gamma. In bioassays, this antiserum neutralizes chIFN-alpha, but not chIFN-beta, and can therefore be used to discriminate IFN alpha and IFN beta bioactivities, see Schwarz, H. et al. for details

Product Specs
ItemRABBIT ANTI CHICKEN INTERFERON ALPHA:Preservative Free
CompanyMyBioSource.com
Price Pricing Info Supplier Page View Company Product Page
Catalog NumberMBS220074
Quantity0.5 mg
ApplicationsELISA (EIA), Functional Assays (FN), Immunoprecipitation (IP), Western Blot (WB)
ConcentrationIgG concentration 0.5 mg/ml
Conjugate/TagUnconjugated
FormatPreservative Free
Purified IgG - liquid
TargetIFN ALPHA
IsotypeIgG
Molecular Weight22,116 Da
HostRabbit
ImmunogenThis item recognizes chicken Interferon alpha (chIFNalpha). The classification of mammalian cytokines with antiviral activity, is well documented as being either Type I Interferon (IFNI) or Type II Interferon (IFNII). This is not the case for avian IFNs however, even though IFN was first detected in the chicken. A growing number of functional studies indicate similarities between chicken IFN and mammalian IFNI, revealing the conservation of cysteine residues and the existence of around ten closely related intron-less IFN alpha genes. Further research has shown that chIFN-alpha genes are strongly expressed following viral infection of monocyte-derived macrophage and embryo fibroblasts and that recombinant chicken IFN acts as a potent antiviral agent. This item cross reacts with IFN beta in western blots but does not show any cross reactivity with IFN gamma. In bioassays, this antiserum neutralizes chIFN-alpha, but not chIFN-beta, and can therefore be used to discriminate IFN alpha and IFN beta bioactivities, see Schwarz, H. et al. for details
NCBI Full Gene Nameinterferon, interferon type A1/A2-like
NCBI Gene AliasesIFN-alpha, IFNA2, IFNA1, IFNA6, IFNA, IFN-gamma
ClonalityPolyclonal